Evidence of peripheral axonal neuropathy in primary restless legs syndrome
Identifieur interne : 005905 ( Main/Exploration ); précédent : 005904; suivant : 005906Evidence of peripheral axonal neuropathy in primary restless legs syndrome
Auteurs : Iannaccone [Italie] ; Marco Zucconi [Italie] ; Paolo Marchettini [Italie] ; Luigi Ferini-Strambi [Italie] ; Raffaello Nemni [Italie] ; Angelo Quattrini [Italie] ; Stefano Palazzi [Italie] ; Marco Lacerenza [Italie] ; Fabio Formaglio [Italie] ; Salvatore Smirne [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 1995-01.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Axonal neuropathy, Axons (pathology), Electromyography, Electrophysiology, Female, Humans, Male, Middle Aged, Peripheral Nerves (pathology), Peripheral Nerves (physiopathology), Peripheral Nervous System Diseases (diagnosis), Peripheral Nervous System Diseases (pathology), Peripheral Nervous System Diseases (physiopathology), Peripheral nerve, Polysomnography, Positive sensory phenomena, Primary restless legs syndrome, Quantitative sensory testing, Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (pathology), Restless Legs Syndrome (physiopathology), Sensory Thresholds, Sleep disorders, Thermal Conductivity.
- MESH :
- diagnosis : Peripheral Nervous System Diseases, Restless Legs Syndrome.
- pathology : Axons, Peripheral Nerves, Peripheral Nervous System Diseases, Restless Legs Syndrome.
- physiopathology : Peripheral Nerves, Peripheral Nervous System Diseases, Restless Legs Syndrome.
- Adult, Age of Onset, Aged, Electromyography, Electrophysiology, Female, Humans, Male, Middle Aged, Polysomnography, Sensory Thresholds, Thermal Conductivity.
Abstract
Restless legs syndrome (RLS) is a well‐defined clinical entity characterized by an unpleasant creeping sensation arising in the legs with an irresistible need to move them. The trouble is more pronounced when the affected people lie in a prolonged rest position and try to fall asleep. It is known that RLS may be consequent to systemic disorders and to diseases affecting the central or peripheral nervous system. The International Classification of Sleep Disorders states that peripheral neuropathy should be ruled out by medical history and clinical grounds before diagnosing primary RLS (pRLS). The present study extended peripheral nerve investigation in eight consecutive pRLS patients with normal neurological examination results and showed that all patients exhibited two or more electrical, psychophysiological, and/or morphological features of peripheral axonal neuropathy. Morphometric analysis of sural nerve showed a significant reduction in myelinated fiber density and g ratio (axon diameter/fiber diameter) in the pRLS group compared with eight control biopsy specimens. These results suggest that axonal neuropathy is often present in patients with RLS. A comprehensive peripheral nerve investigation should be considered in RLS patients.
Url:
DOI: 10.1002/mds.870100103
Affiliations:
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San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Smirne, Salvatore" sort="Smirne, Salvatore" uniqKey="Smirne S" first="Salvatore" last="Smirne">Salvatore Smirne</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Sleep Disorders Centre and Department of Neurology, State University and Istituto Scientifico H. San Raffaele, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1995-01">1995-01</date><biblScope unit="vol">10</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="2">2</biblScope><biblScope unit="page" to="9">9</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DDD1D0730A5161A57A87A5098DDBF75A8AAF82CF</idno><idno type="DOI">10.1002/mds.870100103</idno><idno type="ArticleID">MDS870100103</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Axonal neuropathy</term><term>Axons (pathology)</term><term>Electromyography</term><term>Electrophysiology</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Peripheral Nerves (pathology)</term><term>Peripheral Nerves (physiopathology)</term><term>Peripheral Nervous System Diseases (diagnosis)</term><term>Peripheral Nervous System Diseases (pathology)</term><term>Peripheral Nervous System Diseases (physiopathology)</term><term>Peripheral nerve</term><term>Polysomnography</term><term>Positive sensory phenomena</term><term>Primary restless legs syndrome</term><term>Quantitative sensory testing</term><term>Restless Legs Syndrome (diagnosis)</term><term>Restless Legs Syndrome (pathology)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Sensory Thresholds</term><term>Sleep disorders</term><term>Thermal Conductivity</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Peripheral Nervous System Diseases</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Axons</term><term>Peripheral Nerves</term><term>Peripheral Nervous System Diseases</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Peripheral Nerves</term><term>Peripheral Nervous System Diseases</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Electromyography</term><term>Electrophysiology</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>Sensory Thresholds</term><term>Thermal Conductivity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) is a well‐defined clinical entity characterized by an unpleasant creeping sensation arising in the legs with an irresistible need to move them. The trouble is more pronounced when the affected people lie in a prolonged rest position and try to fall asleep. It is known that RLS may be consequent to systemic disorders and to diseases affecting the central or peripheral nervous system. The International Classification of Sleep Disorders states that peripheral neuropathy should be ruled out by medical history and clinical grounds before diagnosing primary RLS (pRLS). The present study extended peripheral nerve investigation in eight consecutive pRLS patients with normal neurological examination results and showed that all patients exhibited two or more electrical, psychophysiological, and/or morphological features of peripheral axonal neuropathy. Morphometric analysis of sural nerve showed a significant reduction in myelinated fiber density and g ratio (axon diameter/fiber diameter) in the pRLS group compared with eight control biopsy specimens. These results suggest that axonal neuropathy is often present in patients with RLS. A comprehensive peripheral nerve investigation should be considered in RLS patients.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Iannaccone" sort="Iannaccone" uniqKey="Iannaccone" last="Iannaccone">Iannaccone</name></region><name sortKey="Ferini Trambi, Luigi" sort="Ferini Trambi, Luigi" uniqKey="Ferini Trambi L" first="Luigi" last="Ferini-Strambi">Luigi Ferini-Strambi</name><name sortKey="Formaglio, Fabio" sort="Formaglio, Fabio" uniqKey="Formaglio F" first="Fabio" last="Formaglio">Fabio Formaglio</name><name sortKey="Lacerenza, Marco" sort="Lacerenza, Marco" uniqKey="Lacerenza M" first="Marco" last="Lacerenza">Marco Lacerenza</name><name sortKey="Marchettini, Paolo" sort="Marchettini, Paolo" uniqKey="Marchettini P" first="Paolo" last="Marchettini">Paolo Marchettini</name><name sortKey="Nemni, Raffaello" sort="Nemni, Raffaello" uniqKey="Nemni R" first="Raffaello" last="Nemni">Raffaello Nemni</name><name sortKey="Palazzi, Stefano" sort="Palazzi, Stefano" uniqKey="Palazzi S" first="Stefano" last="Palazzi">Stefano Palazzi</name><name sortKey="Quattrini, Angelo" sort="Quattrini, Angelo" uniqKey="Quattrini A" first="Angelo" last="Quattrini">Angelo Quattrini</name><name sortKey="Smirne, Salvatore" sort="Smirne, Salvatore" uniqKey="Smirne S" first="Salvatore" last="Smirne">Salvatore Smirne</name><name sortKey="Zucconi, Marco" sort="Zucconi, Marco" uniqKey="Zucconi M" first="Marco" last="Zucconi">Marco Zucconi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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